IJMS, Free Full-Text
By A Mystery Man Writer
Last updated 24 May 2024
Uterine fibroids are the most common benign tumors in women, with abnormal uterine bleeding (AUB) as the main reported symptom. Additionally, an association between fibroids and infertility has been established, especially if the fibroid protrudes in the uterine cavity. Hormonal therapy is associated with side-effects and as well as hysterectomy, which is incompatible with a desire to conceive. To improve treatment, it is essential to unravel the etiology of fibroid-related symptoms. We aim to evaluate endometrial angiogenesis in women with fibroids, with and without AUB, and the influence of pharmaceutical therapies in these patients. Furthermore, we explore the possible role of altered angiogenesis in patients with fibroids and infertility. We performed a systematic review according to PRISMA-guidelines (PROSPERO: CRD42020169061), and included 15 eligible studies. Endometrial expression of vascular endothelial growth factor (VEGF) and adrenomedullin was increased in patients with fibroids. This suggests aberrant angiogenesis, potentially involving disturbed vessel maturation, resulting in immature and fragile vessels. Treatment with gonadotropin-releasing hormone agonist, ulipristal acetate, and continuous oral contraception pills reduced several angiogenic parameters, including VEGF. If infertile and fertile patients with fibroids were compared, a significant decreased expression of the bone morphogenetic protein/Smad-protein pathway was found, possibly caused by the increased expression of transforming growth factor-beta. For future therapeutic development, these different angiogenic pathways could be of interest as possible targets to treat fibroid-related symptoms.
IJMS, Free Full-Text
IJMS Free Full Text Glucocorticoid Receptor β Isoform Predominates 2680
IJMS, Free Full-Text
IJMS, Free Full-Text, onoo 2 no2
IJMS, Free Full-Text
IJMS Free Full-Text Atorvastatin Attenuates, 40% OFF
IJMS, Free Full-Text
IJMS, Free Full-Text
IJMS, Free Full-Text, test vivo
IJMS, Free Full-Text
IJMS, Free Full-Text
Recommended for you
- Endometriosis: MedlinePlus Medical Encyclopedia14 Jul 2023
- Endometriosis14 Jul 2023
- Endometriosis -Causes, Symptoms, Risk Factors, Diagnoses14 Jul 2023
- NATIONAL ENDOMETRIOSIS AWARENESS MONTH14 Jul 2023
- Your period colours and symptoms; what they mean and how to find their - PCOS To Wellness14 Jul 2023
- March is Endometriosis awareness month. If the average time to14 Jul 2023
- Symptoms of Endometriosis : r/coolguides14 Jul 2023
- Endometriosis symptoms14 Jul 2023
- 6 Uncommon Symptoms of Endometriosis14 Jul 2023
- Endometriosis happens when tissue similar to the lining of the uterus (womb) grows outside of the uterus. Symptoms of endometriosis…14 Jul 2023
You may also like
- 3 PCS Lace Siamese Sexy Lingerie Erotic Underwear, Size:L(Black14 Jul 2023
- Black Squares Women's Fancy Leggings14 Jul 2023
- Nyx contour pallet14 Jul 2023
- Sample Royal Stewart Tartan Ribbon14 Jul 2023
- 🖤 URBAN OUTFITTERS 🖤 Black lace bralette from Urban - Depop14 Jul 2023
- Shapewear & Solutions, Plunge & Thong Shapewear14 Jul 2023
- Men's Tummy Control Body Shaper Underwear Body Toning T-shirt Girdle Shirts Vest14 Jul 2023
- Roxy Rising High Technical Snow Pants Womens14 Jul 2023
- Mid Blue Perfect Jeggings14 Jul 2023
- Jinx Was Here Arcane League of Legends T Shirt Classic Graphic Big size Crewneck TShirt Big14 Jul 2023